Cardarine GW501516 10MG

Description

Sarmsamerica manufactures Cardarine for sale at the highest quality and potency available. Also known as Cardarine GW 501516 or Endurobol, this compound is a PPARδ receptor agonist. These receptors regulate various biological processes within the body. Research indicates that GW-501516 binds to these receptors, activating AMP-activated protein kinase (AMPK). According to studies, AMPK plays a crucial role in energy regulation and helps the body survive metabolic stress. By activating AMPK, GW-501516 can significantly boost fat loss and increase overall energy output.

High-Quality Cardarine for Sale

Trust Sarmsamerica as your number-one source to buy SARMs online. This Cardarine SARM, known for its endurance-boosting benefits, enhances energy levels and improves recovery time. GW-501516 can help lower LDL cholesterol and increase muscle mass, helping you look and feel your best. Our GW-501516 Cardarine capsules are 10 mg each and come in a bottle of 60. Order your Cardarine SARMs for sale today from Sarmsamerica.

About Cardarine SARM

Cardarine SARMs are not your typical SARM; in fact, they are peroxisome proliferator-activated receptor delta (PPARδ) agonists. This specific receptor is one of three members of the PPAR group and acts as a ligand-activated transcription factor. Cardarine assists with metabolic functions and plays a crucial role in maintaining energy levels. Like many compounds, Cardarine is known by various names, including GW1516, GSK-516, and Endurobol. It has shown potential in aiding fat burning and possibly preventing obesity in users.

• Increases fatty acid oxidation and promotes fat loss
• Lower LDL cholesterol (“bad cholesterol”)
• Higher HDL cholesterol (“good cholesterol”)
• Increases endurance
• Reduces inflammation
• Decreases insulin resistance and improves glucose tolerance

Studies on Cardarine

The Brain 

Numerous studies have explored the diverse potential of Cardarine SARMs. These research investigations have examined its effects on obesity, cognitive function, and muscle growth. The findings from these trials are as follows.

In a study focused on brain function, researchers used a cluster of brain cell cultures derived from embryonic rat brains, rather than live rats. They employed GW 501516 to investigate inflammatory responses induced by IFN-gamma and lipopolysaccharide (LPS).

Interferon-gamma (IFN-gamma) is a dimerized soluble cytokine, the sole member of the type II class of interferons. This means it combines with similar molecules to form a dimer, a structure composed of two identical molecules linked together.

Lipopolysaccharides are large molecules composed of a lipid and polysaccharide, located in the outer membrane of gram-negative bacteria. The study aimed to observe the effects of GW 501516 on these substances. The results showed that GW 501516 reduced the IFN-gamma-induced upregulation of TNF-alpha and iNOS, demonstrating significant anti-inflammatory effects.

Maintaining Heart Health with Cardarine

In a twelve-week study, participants were administered varying dosages of GW-501516 (Cardarine), including 2.5mg, 5.0mg, and 10mg. The study involved relatively healthy individuals with high-density lipoprotein (HDL) levels below 1.16mmol/L.

When the study was at the beginning stages, certain levels were taken in order to create a baseline for the participants involved. Fasting insulin, glucose, lipids, and free fatty acid levels were of the levels taken for said baseline. By the end of this twelve-week study, those involved had experienced a significant change in both cholesterol levels, meaning HDL and LDL. It was therefore concluded that GW 501516 has potential as a cardiovascular protection compound.

Obesity and Weight Loss with Cardarine SARMs

Two significant studies have been conducted on Cardarine, focusing on its potential to aid in obesity and weight loss.

In a smaller scale study at the University of Maryland, six rhesus monkeys were placed on a diet consisting of 13% fat, 18% protein, and 69% carbohydrates. Researchers studied the effects of GW 501516, initially administering doses of 0.1mg/kg daily. By the end of the study, the dosage was increased to 3.0mg/kg per day. The findings revealed that giving the monkeys a “treat” twice daily containing the compound led to a reduction in food consumption, indicating its potential in aiding obesity.

In a second study, wild-type mice were placed on a high-fat diet, consisting of 35% fat content compared to the usual 4%. Over two months, these mice experienced a 30% increase in body weight, along with improved glucose tolerance and a reduction in fat mass.

Potential Benefits of Cardarine in Research

Cardarine (GW501516) has been the subject of various preclinical studies, with researchers exploring its potential effects on endurance, metabolism, and muscle preservation. Here are some findings based on scientific investigations:

1. Increased Endurance: Research suggests Cardarine may enhance stamina by activating pathways that improve energy utilization during physical activity.
2. Metabolic Support: Studies indicate Cardarine may improve lipid metabolism and promote fat oxidation, making it a compound of interest in obesity and metabolic health research.
3. Muscle Preservation: Cardarine has been studied for its ability to help maintain lean muscle mass during calorie deficits, particularly in preclinical models.

Important Considerations and Potential Drawbacks

1. Insufficient Human Studies:
   • Large-scale human trials have not been conducted to fully understand the long-term effects and safety profile of Cardarine. Most of the available data comes from animal studies and limited clinical trials, which leaves room for further investigation.
2. Cancer Risk in Animal Studies:
   • In preclinical research, high doses of Cardarine were associated with an increased risk of tumor development in laboratory animals. While these findings require more context and investigation, they underscore the importance of cautious use in experimental settings.
3. Contraindications:
   • Cardarine is not recommended for use in pregnancy or among individuals planning to become pregnant, as research suggests it may have developmental effects on the fetus.

Side Effects of Cardarine

While Cardarine is not known to cause androgenic side effects like anabolic androgenic steroids, data from rat studies indicates that doses of 3mg/kg/day (equivalent to 180-240mg per day in an average 60-80kg adult) are significantly higher than those used in mammalian trials, caused rapid cancer development in several organs. Anecdotal evidence online reports minimal noticeable side effects, but more research is needed to determine the overall safety profile of GW501516 before it can be approved for human use by the FDA.

Experimental Administration Protocol for Cardarine Capsules

Cardarine SARM is straightforward regarding dosages. If you plan to start a cycle of GW 501516, the typical cycle length is about eight weeks. The dosage changes once during the cycle and then remains consistent. For the first week, it is recommended to start at 10mg to allow your body to acclimate to GW 501516. After the initial week, you can increase the dose to 20mg per day for the remainder of the cycle. Unlike compounds such as RAD 140 or Ostarine, completing a Post Cycle Therapy (PCT) is not necessarily required with Cardarine. However, it’s still important to give your body time off after the cycle to recuperate.

Cardarine GW501516 Molecule

Data on Our Cardarine for Sale

Cardarine FAQ

Can Cardarine suppress natural testosterone?

GW 501516 does not interact with the androgen receptor, so it does not cause suppression of natural testosterone levels.

Does Cardarine affect menstrual cycles in females?

Cardarine is non-hormonal and is not known to disrupt menstrual cycles or cause virilization in female test subjects. Clinical trials have used quantities as high as 18mg per day for females. However, pregnant women or those who may become pregnant should not participate in clinical research involving Cardarine.

Does Cardarine improve cholesterol?

GW501516 has been shown to increase HDL (high-density lipoprotein) and decrease LDL (low-density lipoprotein) levels in rhesus monkeys.

Is Cardarine a SARM?

While Cardarine is often marketed alongside SARMs, it is actually a PPAR agonist. It binds to and activates PPAR receptors in the body, which play a limited role in anabolism. Instead, these receptors are primarily involved in reducing inflammation and improving energy metabolism.

Why is Sarmsamerica the best place to buy Cardarine online?

A recent study involving chemical analyses of 44 different products sold and marketed as SARMs on the Internet revealed significant variability in quality control across the industry. Only 52% of the products contained the advertised substance, 59% had different amounts than stated on the label, 39% contained other unapproved compounds, 25% included substances not listed on the label, and 9% had no active ingredient at all. Therefore, it is critical to purchase SARMs only from sources that provide high-quality products verified by third-party analysis when conducting research.

If you are looking to buy Cardarine, which is considered by many researchers to be one of the best SARMs for cutting body fat, there are plenty of options available. Sarmsamerica is the best place to buy Cardarine online due to their consistent, verifiable high-quality products, safe bottling and packaging, fast shipping, and excellent customer service. Our Cardarine is available in capsule form.

When you buy SARMs from Sarmsamerica, you are choosing the highest quality ingredients. Our compounds are a minimum of 98% pure, tested and certified by accredited American third-party labs and suspended in USP grade PEG400, the highest grade available.

We run a transparent business with no need for discreet payment methods and no misrepresentation of our products. We offer only the highest quality research chemicals available online. Enjoy free shipping on orders over $160, and if you need your products quickly, we offer express shipping as well. Plus, customers who sign up for our email list receive a 10% discount.

Ready to start your journey with Cardarine today? Sarmsamerica offers top-quality, authentic peptides, SARMs, and research chemicals. When you buy SARMs online from us, you will receive high-quality Cardarine SARMs in a container with 60 capsules, each containing 10mg. We adhere to the highest testing standards for all our products, ensuring that you receive only the best. Buy your high-quality SARMs online from Sarmsamerica today.

At Sarmsamerica, you can find SARMs for sale, including the highest quality Cardarine available anywhere on the internet. We are confident in our claim that we offer the best GW 501516 for sale on the market today. If you have any questions about our GW501516 products, you can contact us, and we’ll respond as soon as possible.

Abuse Warning

Cardarine is an investigational compound still awaiting FDA approval and is not a dietary supplement. At Sarmsamerica, we are chemical suppliers, not medical doctors, and our expertise lies in sourcing and quality control. Sarmsamerica does not encourage or condone consumer use of SARM products; they are intended for research purposes only.

SARMs should only be used under the supervision and direction of a medical doctor or designated research authority. We strongly discourage using SARMs for performance enhancement in sports and bodybuilding as these products are not FDA-approved. We warn against relying on “bro science” and peer consensus when making decisions about participating in an authorized clinical trial with these compounds.

Scientific References:

1. T. Tanaka et al., Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome, Proc. Natl. Acad. Sci. U.S.A., vol. 100, no. 26, pp. 15924–15929, Dec. 2003
2. Chen, W. et al. A metabolomic study of the PPARd agonist GW501516 for enhancing running endurance in Kunming mice. Sci. Rep. 5, 09884; doi: 10.1038/srep09884 (2015)
3. Fan W., Waizenegger W., Lin C.S., Sorrentino V., He M.-X., Wall C.E., Li H., Liddle C., Yu R.T., Atkins A.R., et al. PPARδ Promotes Running Endurance by Preserving Glucose. Cell Metab. 2017;25:1186–1193.e1184. doi: 10.1016/j.cmet.2017.04.006
4. What is GW501516 (aka cardarine) Sports Technology Labs 2023.
5. Oliver WR Jr, Shenk JL, Snaith MR, Russell CS, Plunket KD, Bodkin NL, Lewis MC, Winegar DA, Sznaidman ML, Lambert MH, Xu HE, Sternbach DD, Kliewer SA, Hansen BC, Willson TM. A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5306-11. doi: 10.1073/pnas.091021198. Epub 2001 Apr 17. PMID: 11309497; PMCID: PMC33205.
6. Sprecher DL. Lipids, lipoproteins, and peroxisome proliferator activated receptor-delta. Am J Cardiol. 2007 Dec 3;100(11 A):n20-4. doi: 10.1016/j.amjcard.2007.08.009. PMID: 18047848.
7. Barish GD, Narkar VA, Evans RM. PPAR delta: a dagger in the heart of the metabolic syndrome. J Clin Invest. 2006 Mar;116(3):590-7. doi: 10.1172/JCI27955. PMID: 16511591; PMCID: PMC1386117.
8. Dressel U, Allen TL, Pippal JB, Rohde PR, Lau P, Muscat GE. The peroxisome proliferator-activated receptor beta/delta agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells. Mol Endocrinol. 2003 Dec;17(12):2477-93. doi: 10.1210/me.2003-0151. Epub 2003 Oct 2. PMID: 14525954.
9. Sahebkar A, Chew GT, Watts GF. New peroxisome proliferator-activated receptor agonists: potential treatments for atherogenic dyslipidemia and non-alcoholic fatty liver disease. Expert Opin Pharmacother. 2014 Mar;15(4):493-503. doi: 10.1517/14656566.2014.876992. Epub 2014 Jan 16. PMID: 24428677.
10. Teresa Coll, David Álvarez-Guardia, Emma Barroso, Anna Maria Gómez-Foix, Xavier Palomer, Juan C. Laguna, Manuel Vázquez-Carrera, Activation of Peroxisome Proliferator-Activated Receptor-δ by GW501516 Prevents Fatty Acid-Induced Nuclear Factor-κB Activation and Insulin Resistance in Skeletal Muscle Cells, Endocrinology, Volume 151, Issue 4, 1 April 2010, Pages 1560–1569
11. Magliano, D.C., Penna-de-Carvalho, A., Vazquez-Carrera, M. et al. Short-term administration of GW501516 improves inflammatory state in white adipose tissue and liver damage in high-fructose-fed mice through modulation of the renin-angiotensin system. Endocrine 50, 355–367 (2015).
12. Van Wagoner RM, Eichner A, Bhasin S, Deuster PA, Eichner D. Chemical Composition and Labeling of Substances Marketed as Selective Androgen Receptor Modulators and Sold via the Internet. JAMA. 2017 Nov 28;318(20):2004-2010. doi: 10.1001/jama.2017.17069. Erratum in: JAMA. 2018 Feb 20;319(7):724. PMID: 29183075; PMCID: PMC5820696.
13. Burri L, Thoresen GH, Berge RK. The Role of PPARα Activation in Liver and Muscle. PPAR Res. 2010;2010:542359. doi: 10.1155/2010/542359. Epub 2010 Aug 18. PMID: 20847941; PMCID: PMC2933910.
14. Leone TC, Weinheimer CJ, Kelly DP. A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7473-8. doi: 10.1073/pnas.96.13.7473. PMID: 10377439; PMCID: PMC22110.
15. Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, Wahli W. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest. 1999 Jun;103(11):1489-98. doi: 10.1172/JCI6223. PMID: 10359558; PMCID: PMC408372
16. https://www.ajconline.org/article/S0002-9149(07)01592-5/abstract
17. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492977/
18. https://www.toxicology.org/pubs/docs/Tox/2009Tox.pdf
19. https://academic.oup.com/mend/article/17/12/2477/2747399
20. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1386117/

*Disclaimer: These products are not intended to diagnose, treat, or cure any condition or disease.