Description
Research has identified CJC-1295 with DAC as a growth hormone Peptide. It is primarily used in studies to stimulate growth hormone release from the pituitary gland. Studies indicate that growth hormone plays a crucial role in several vital functions within the body.
High Quality CJC-1295 for sale online
The theoretical framework suggests that administering CJC-1295 allows it to bind to specific receptors within the pituitary gland. This interaction may trigger a series of biological events, resulting in increased secretion and circulation of growth hormones throughout the body.
This notion stems from preclinical studies where researchers observed elevated hormone levels following administration of CJC-1295.
Action Mechanism
CJC-1295 functions by imitating the natural Growth Hormone Releasing Hormones (GHRH) produced by the body. This chemical similarity enables it to effectively bind with GHRH receptors on cells in the anterior pituitary gland.
This action increases growth hormone production and secretion into the systemic circulation, resulting in elevated levels of human growth hormone. Research studies have shown that these elevated levels can last several days after administering CJC-1295.
Sustained Effects
A unique characteristic of CJC-1295 with DAC is its extended half-life compared to other Peptides commonly used for scientific research. It forms stable bonds with albumin in blood plasma through bioconjugation, thereby prolonging its presence and effectiveness within the body.
Compared to other Peptides, which often have short-lived effects due to rapid degradation or excretion, researchers have observed that CJC-1295 results in sustained elevated levels of human growth hormone for longer periods post-administration.
Indirect IGF-I Production Role
Beyond directly stimulating growth hormone release, CJC-1295 also plays a crucial role in influencing Insulin-like Growth Factor-I (IGF-I). When growth hormone is released into the bloodstream, a portion travels to liver cells, where it stimulates the synthesis of IGF-I.
In experimental settings, administration of CJC-1295 results in increased serum concentrations of both growth hormone (GH) and Insulin-like Growth Factor-I (IGF-I). Studies have shown that these hormones work synergistically to promote cell proliferation and support various biological functions.
DAC: Drug Affinity Complex’s Role in Stability
In the context of CJC-1295 DAC, ‘DAC’ stands for Drug Affinity Complex. This complex, invented by renowned researcher John J. Kopchick at Ohio University, extends the half-life of CJC-1295, allowing it to remain active longer than naturally occurring GRF.
This extended duration results from CJC-1295 DAC’s ability to bind with serum albumin and gradually release over time. This characteristic makes it ideal for long-term studies that require sustained HGH stimulation, providing significant potential benefits.
Normalization Of Growth In GHRH Knockout Mice
The majority of children with isolated growth hormone (GH) deficiency typically respond well to GH-releasing hormone (GHRH) therapy; however, its short half-life limits its effectiveness. In GHRH knockout (GHRHKO) mice, which lack the GHRH gene, even twice-daily injections of a GHRH analog fail to normalize growth. CJC-1295, a synthetic GHRH analog, binds to endogenous albumin after injection, extending its half-life and action duration. This study evaluates the effects of CJC-1295 in GHRHKO mice, with three groups of GHRHKO mice treated for 5 weeks at different intervals.
Daily doses of CJC-1295 maintained normal body weight and length in GHRHKO mice, while injections every 48 and 72 hours resulted in higher body weight and length but did not fully normalize growth. Femur and tibia lengths were normal with injections every 24 and 48 hours, and lean and fat mass were normal across all treatment groups. CJC-1295 also increased total pituitary RNA and GH mRNA, indicating somatotroph cell proliferation, supported by immunohistochemistry images. In conclusion, once-daily CJC-1295 administration maintained normal body composition and growth in GHRHKO mice, but was less effective when given every 48 or 72 hours.
Data on our CJC1295 DAC for sale
| CAS Number: | 863288-34-0 |
| Formula: | C152H252N44O42 |
| Sequence: | Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala- Arg-Lys-LeuLeu-Gln-Asp-Ile-Leu-Ser-Arg-Lys |
| Molar Mass: | 3367.9 g/mol |
| Half life: | 6-8 days |
| Class: | Peptide |
| Storage: | Keep refrigerated upon reconstitution.
|
CJC-1295 FAQs
What Is CJC 1295?
CJC-1295 with DAC was developed by ConjuChem Biotechnologies, with DAC standing for Drug Affinity Complex. CJC-1295 DAC is a synthetic analog of growth hormone-releasing hormone, also known as growth hormone-releasing factor, making it a growth hormone secretagogue. This means that CJC-1295 with DAC helps stimulate the secretion of growth hormone.
CJC-1295 with DAC works by increasing IGF-1 and plasma growth hormone levels. Bioconjugation is a chemical strategy that forms a stable bond between two molecules, which is crucial because it allows CJC-1295 with DAC to extend the half-life and bioavailability of growth hormone-releasing hormone 1-29. This process enhances its effectiveness and duration of action.
What does CJC1295 do?
CJC-1295 stimulates growth hormone secretion from the pituitary gland. Research has shown that CJC-1295 can increase growth hormone levels by 200-1000% for several days.
Are CJC-1295 and Ipamorelin the same
Ipamorelin is a ghrelin agonist that stimulates both appetite and growth hormone production. Meanwhile, CJC-1295 promotes the release of growth hormone from the pituitary gland.
Does CJC-1295 build muscle?
By stimulating the secretion of growth hormone, CJC-1295 may contribute to increased lean muscle growth. However, more research is needed to validate these findings.
What is the difference between CJC-1295 and CJC-1295 with DAC?
CJC-1295 with DAC is designed for enhanced stability and an extended half-life.
What is the strongest HGH Peptide?
Research indicates that CJC-1295 can increase growth hormone levels by 200-1000%, with elevated hormone production continuing for up to 6 days. This makes CJC-1295 an effective Peptide for increasing muscle mass and strength.
Why buy CJC 1295 DAC from Sarmsamerica?
If you’re looking to buy CJC 1295 DAC, finding a seller is easy, but Sarmsamerica is the best place to buy CJC-1295 online. They offer consistent, verifiable high-quality products, fast shipping, and excellent customer service. A quick search will reveal plenty of CJC-1295 reviews from companies specializing in Peptides.
However, the simple truth is that not all of these companies are trustworthy. In many cases, you can’t be certain of what you’re getting when you buy Peptides from them.
At Sarmsamerica, you can confidently purchase the highest quality CJC1295 DAC, as every batch is third-party tested by a US-based laboratory, ensuring a certified minimum purity of 98%.
Our research chemicals are lyophilized in glass vials and stored refrigerated to maintain potency. We operate a transparent business, avoiding discreet payment methods and ensuring no misrepresentation of our products. Explore the highest quality online.
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If you have any questions about our CJC 1295 for sale for laboratory research use, please don’t hesitate to contact us.
References:
- Sackmann-Sala, L., Ding, J., Frohman, L. A., & Kopchick, J. J. (2009). Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects. Growth Hormone & IGF Research, 19(6), 471-477.
- Van Hout, M. C., & Hearne, E. (2016). Netnography of female use of the synthetic growth hormone CJC-1295: pulses and potions. Substance Use & Misuse, 51(1), 73-84.
- Alba, M., Fintini, D., Sagazio, A., Lawrence, B., Castaigne, J. P., Frohman, L. A., & Salvatori, R. (2006). Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. American Journal of Physiology-Endocrinology and Metabolism, 291(6), E1290-E1294.
- Knoop, A., Thomas, A., Fichant, E., Delahaut, P., Schänzer, W., & Thevis, M. (2016). Qualitative identification of growth hormone-releasing hormones in human plasma by means of immunoaffinity purification and LC-HRMS/MS. Analytical and Bioanalytical Chemistry, 408, 3145-3153.
- McDonald J, Lambert DG. Drug-receptor interactions in anaesthesia. BJA Educ. 2022Jan;22(1):20-25. doi: 10.1016/j.bjae.2021.07.009. Epub 2021 Oct 14. PMID: 34992797; PMCID: PMC8703152.
Disclaimer: The CJC-1295 with DAC listed on this site is sold exclusively for research purposes and is not intended for human consumption. This product is not a compound, supplement, food, or cosmetic and must not be misused, sold, labeled, or branded as such. It is not intended to diagnose, treat, or cure any condition or disease. It is strictly for research use only.
