GHRP-2 5MG

Description

For research purposes, GHRP-2 (Pramorelin) has been referred to by various names including pralmorelin, KP-102 D, and KP 102 LN, among others. In research reports, GHRP-2 is frequently studied for its role as a growth hormone-releasing Peptide. Its primary action involves acting as an analog of met-enkephalin. Essentially, GHRP-2 functions as both a ghrelin and growth hormone receptor agonist, stimulating the secretion of growth hormone.

High-Quality GHRP-2 for Sale Online

GHRP-2 or Pramorelin is available from Sarmsamerica in white powder form, conveniently packaged in vials containing a 5 mg dose. Our GHRP-2 is pharmaceutical grade, ideal for research and laboratory use. This synthetic Peptide is specifically designed as a supplemental growth hormone.

While the human body naturally produces growth hormone, many children and elderly individuals experience growth hormone deficiency (GHD). GHRP-2 is similar to GHRP-6 but does not stimulate appetite in the same manner as GHRP-6.

Molecular Mechanisms of GHRP-2 at the Ghrelin Receptor

Ghrelin, a Peptide recently identified as secreted by gastric endocrine cells (1), has garnered significant interest for its dual effects. This endogenous ligand for the growth hormone secretagogue receptor (GHS-R), cloned in 1996 (2), regulates growth hormone (GH) release (3). Ghrelin also plays a role in regulating food intake and energy balance. Administration of ghrelin to rodents, whether centrally or peripherally, increases food intake and body weight (4,5). Importantly, its effects on food intake are independent of GH secretion (4,6-8) and seem to be mediated through NPY/Agouti gene-related protein (AGRP) neurons in the hypothalamic arcuate nucleus (9,10). Recent studies have shown that peripheral administration of ghrelin stimulates food intake in lean, healthy individuals (11) and in cancer patients (12).

Data indicate that circulating ghrelin is involved in meal-to-meal regulation. Ghrelin levels rise in anticipation of a meal (13) and decrease following food intake (13, 14). However, the specific mechanisms underlying these processes are not fully understood. The suppression of ghrelin after a meal is correlated with the carbohydrate (CHO) content of the meal but does not seem to be directly influenced by glucose or insulin levels (14,15), although administration of insulin has been shown to decrease ghrelin (16).

Serum ghrelin levels fluctuate depending on energy balance. Ghrelin levels are elevated in conditions like anorexia (17) and reduced in obesity (18). Therefore, ghrelin may play a significant role in food intake behaviors and potentially in chronic states of over- and undernutrition (19). Due to its dual effects, ghrelin serves as a crucial hormonal signal of nutritional status to the somatotropic axis, influencing the integration of energy balance and growth processes (20).

GHRP-2 Pramorelin Molecule

Data on Our GHRP 2 for Sale

GHRP-2 FAQs

What Does GHRP-2 Do?

GHRP-2 is considered a true hGH secretagogue, meaning it stimulates the body’s own secretion of human growth hormone (hGH). Studies have shown that human growth hormone promotes lean body mass and reduces adiposity (fat). GHRP-2 has demonstrated high effectiveness in stimulating GH production in research test subjects.

Does GHRP-2 Increase Testosterone?

Only GnRH pulses combined with GHRP-2 and TRH infusion significantly increased testosterone from day 2 (with a peak increase of +312%) through day 5, and serum E2 by more than 80% from day 1 through day 3 (all P = 0.05). Ureagenesis was reduced by both GHRP-2 + TRH + GnRH (P = 0.01) and GHRP-2 + TRH (P = 0.009), but not by GHRP-2 alone.

What Are the Long-Term Effects of GHRP-2?

This is the first report of the therapeutic effects of long-term intranasal administration of the ghrelin agonist GHRP-2 in a severely emaciated, long-standing anorexia nervosa (AN) patient. GHRP-2 increased appetite, body weight, and muscle strength, and improved fatigue, gastrointestinal functions, and hypoglycemia.

Is It Safe to Take GHRP-2?

Limited human data exist to inform safety-related considerations. Compounded drugs containing GHRP-2 for injectable and nasal use may pose immunogenicity risks due to potential aggregation and Peptide-related impurities.

Why Buy GHRP-2 from Sarmsamerica?

If you’re considering where to buy Growth Hormone Releasing Peptide 2 (GHRP-2), it’s crucial to choose a reputable supplier. Buying Peptides from a randomly selected company can pose risks.

Most companies with Peptides for sale unfortunately do not conduct testing on their products or provide transparency regarding certificates and contact information for their third-party labs. This lack of transparency raises questions about what they may be concealing regarding product quality and safety.

Discover the highest quality GHRP-2 for sale online at Sarmsamerica. When you buy Peptides from Sarmsamerica, you are assured of receiving premium-quality products. Our pure compounds are rigorously tested and certified by accredited American third-party laboratories, which can be contacted directly to verify the authenticity of their certificates.

Our products are lyophilized in glass bottles and kept refrigerated to maintain their integrity during storage. We operate with full transparency, avoiding discreet payment methods and ensuring no misrepresentation of our offerings. We provide only the highest quality research chemicals available online.

We offer free shipping for orders of $160 or more, with express shipping options available for those needing their products quickly. Customers who join our email list receive a 10% discount.

Sarmsamerica is the best place to buy GHRP-62 online, offering consistently high-quality, verifiable products, secure bottling and packaging, swift shipping, and exceptional customer service. If you have any questions about our GHRP-2 or other products, feel free to contact us for a prompt response.

Scientific References:

1. 1. ChEBI
      • Pralmorelin
        • https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:135890
      • ChEBI Ontology
        • http://www.ebi.ac.uk/chebi/userManualForward.do#ChEBI%20Ontology
   2. ChEMBL
      • LICENSE
        • Access to the web interface of ChEMBL is made under the EBI’s Terms of Use (http://www.ebi.ac.uk/Information/termsofuse.html). The ChEMBLdata is made available on a Creative Commons Attribution-Share Alike 3.0 Unported License (http://creativecommons.org/licenses/by-sa/3.0/).
        • http://www.ebi.ac.uk/Information/termsofuse.html
        • https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL106593/ 
   3. ChemIDplus
      • LICENSE
        • https://www.nlm.nih.gov/copyright.html
      • Pralmorelin [INN]
        • https://pubchem.ncbi.nlm.nih.gov/substance/?source=chemidplus&sourceid=0158861677
      • ChemIDplus Chemical Information Classification
        • https://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus
   4. DrugBank
      • LICENSE
        • Creative Common’s Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/legalcode)
        • https://www.drugbank.ca/legal/terms_of_use 
      • Pralmorelin
        • https://www.drugbank.ca/drugs/DB18252
   5. EPA DSSTox
      • LICENSE
        • https://www.epa.gov/privacy/privacy-act-laws-policies-and-resources
      • Pralmorelin
        • https://comptox.epa.gov/dashboard/DTXSID601032404
      • CompTox Chemicals Dashboard Chemical Lists
        • https://comptox.epa.gov/dashboard/chemical-lists/
   6. FDA Global Substance Registration System (GSRS)
      • LICENSE
        • Unless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.
        • https://www.fda.gov/about-fda/about-website/website-policies#linking
      • Pralmorelin
        • https://gsrs.ncats.nih.gov/ginas/app/beta/substances/E6S6E1F19M
   7. Drug Gene Interaction database (DGIdb)
      • LICENSE
        • The data used in DGIdb is all open access and where possible made available as raw data dumps in the downloads section.
        • http://www.dgidb.org/downloads
      • Pralmorelin
        • https://www.dgidb.org/drugs/ncit:C80257
   8. IUPHAR/BPS Guide to PHARMACOLOGY
      • LICENSE
        • The Guide to PHARMACOLOGY database is licensed under the Open Data Commons Open Database License (ODbL)https://opendatacommons.org/licenses/odbl/. Its contents are licensed under a Creative Commons Attribution-ShareAlike 4.0 InternationalLicense (http://creativecommons.org/licenses/by-sa/4.0/)
        • https://www.guidetopharmacology.org/about.jsp#license
      • Pralmorelin
        • https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1092
      • Guide to Pharmacology Target Classification
        • https://www.guidetopharmacology.org/targets.jsp
   9. Therapeutic Target Database (TTD)
      • GHRP-2
        • https://idrblab.net/ttd/data/drug/details/D08VRX
   10. Japan Chemical Substance Dictionary (Nikkaji)
       • http://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J623.307D
   11. NCI Thesaurus (NCIt)
       • • Unless otherwise indicated, all text within NCI products is free of copyright and may be reused without our permission. Credit the National Cancer Institute as the source.
         • https://www.cancer.gov/policies/copyright-reuseLICENSE
       • NCI Thesaurus Tree
         • https://ncit.nci.nih.gov 
   12. Wikidata
       • LICENSE
       • CCZero
         • https://creativecommons.org/publicdomain/zero/1.0/
       • Pralmorelin
         • https://www.wikidata.org/wiki/Q21098924
   13. Wikipedia
       • Pralmorelin
         • https://en.wikipedia.org/wiki/Pralmorelin
   14.  PubChem
       • https://pubchem.ncbi.nlm.nih.gov
   15. Medical Subject Headings (MeSH)
       • LICENSE
         • Works produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.
         • https://www.nlm.nih.gov/copyright.html
       • Growth Hormone-Releasing Peptide-2
         • https://www.ncbi.nlm.nih.gov/mesh/67091874
       • MeSH Tree
         • http://www.nlm.nih.gov/mesh/meshhome.html
       • Growth Substances
         • https://www.ncbi.nlm.nih.gov/mesh/68006133
   16. PATENTSCOPE (WIPO)
       • SID 389885299
         • https://pubchem.ncbi.nlm.nih.gov/substance/389885299

Disclaimer: The GHRP-2 available on this site is strictly for research use only and is not intended for human consumption. This product is not a compound, supplement, food, or cosmetic and must not be misused, sold, labeled, or branded as such. These products are not designed to diagnose, treat, or cure any condition or disease. They are solely for research purposes and not for human use.