Description
Buy MOTS-c for sale at Sarmsamerica. MOTS-c is a Mitochondrial-Derived Peptide. It is encoded by the mitochondrial DNA, unlike most proteins which are encoded by nuclear DNA. MOTS-c plays a crucial role in regulating metabolic functions. It is involved in cellular energy homeostasis, insulin sensitivity, and glucose metabolism. Find MOTS-c Peptide for sale at Sarmsamerica today.
High-Quality MOTS-c Peptide for Sale Online
MOTS-c has gained significant attention recently for its therapeutic potential in various processes, including weight regulation, metabolism, longevity, exercise capacity, skeletal muscle growth, and disease-related pathways.
MOTS-c and Metabolic Regulation and Energy Utilization
Fat Breakdown and Energy Boost
Studies in mice have shown that MOTS-c treatment induces metabolic changes that regulate the body’s energy utilization. MOTS-c acts in the nucleus to alter gene expression, resulting in enhanced fat breakdown and increased energy levels.
In the absence of MOTS-c, elevated fat levels in the bloodstream and disrupted energy regulation can occur, necessitating increased insulin levels. This condition can eventually lead to insulin resistance.
MOTS-c treatment in mice has demonstrated positive effects on brown fat function, including preventing inflammation, reducing fatty tissue buildup, and mitigating weight gain, even on a high-fat diet.
Improved Glucose Absorption and Insulin Sensitivity
Research indicates that MOTS-c treatment enhances the delivery of glucose carriers in muscles by improving the muscle response to AMP-activated protein kinase (AMPK) activation.
Activation of the AMPK pathway drives glucose and fatty acid uptake by cells for metabolism. MOTS-c can enhance glucose uptake into skeletal muscle even in the absence or dysfunction of insulin, indicating its potential for weight management, fat mass reduction, and insulin resistance treatment.
Additionally, MOTS-c influences nuclear gene expression by regulating genes involved in glucose restriction and antioxidant responses following metabolic stress.
MOTS-c Peptide and Collagen Synthesis and Bone Health
MOTS-c has shown potential in promoting collagen synthesis and strengthening bones and skeletal muscles by regulating the TGF-beta/SMAD pathway.
MOTS-c increases osteoblast survival and promotes the development of new stem cells within the bone marrow, leading to the formation of new bone tissue. These effects contribute to maintaining bone health and potentially mitigating age-related physical decline and muscle loss.
MOTS-c and Longevity and Mitigation of Age-Related Decline
A specific substitution of glutamate with lysine in the MOTS-c protein has been linked to longevity and the mitigation of age-related physical decline and muscle loss in certain human populations, particularly those of Northeast Asian ancestry.
This substitution alters the structure and function of the MOTS-c gene and may contribute to promoting longevity. Understanding mitochondrial biology and its impact on lifespan and human health is crucial, and Peptides like MOTS-c offer potential avenues for directly influencing mitochondrial function without the need for dietary restrictions.
MOTS c Peptide and Improvement of Endothelial Cell Function
MOTS-c may also enhance the health of endothelial cells, which line the blood vessels and regulate crucial functions such as blood pressure, blood clotting, and plaque formation.
Lower levels of MOTS-c have been associated with higher levels of endothelial cell dysfunction. Research in rats suggests that MOTS-c enhances the sensitivity of endothelial cells to other signaling molecules, such as acetylcholine, even though it does not directly affect blood vessel responsiveness.
In mice fed a high-fat diet, MOTS-c administration has shown improvements in endothelial function as well as microvascular and epicardial blood vessel function.
Data on our MOTS-c for Sale
| CAS Number: | 1627580-64-6 |
| Formula: | C101H152N28O22S2 |
| Sequence: | H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH |
| Molar Mass: | 2174.6 g/mol |
| Class: | Polypeptide |
| Storage: | Keep refrigerated upon reconstitution.
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MOTS-c FAQs
What Is MOTS-c Used For?
MOTS-c plays a crucial role in regulating glucose metabolism in skeletal muscle cells and is being studied for its potential effects on cardiovascular disease, diabetes, and longevity.
What Is MOTS-c Treatment?
MOTS-c improves metabolic homeostasis and alleviates insulin resistance. Initial studies on MOTS-c observed modest reductions in body weight, food intake, and blood glucose levels in MOTS-c-treated high-fat diet (HFD)-fed mice
Does MOTS-c Really Work?
MOTS-c administration significantly improved physical performance in mice of various ages, regulated skeletal muscle metabolism and gene expression, and enhanced adaptation to metabolic stress.
Does MOTS-c Lead to Weight Loss?
MOTS-c has shown significant improvements in metabolic homeostasis and insulin sensitivity.
What Does MOTS-c Do for Energy?
MOTS-c is a relatively new Peptide consisting of 16 amino acids that promote metabolic balance. It regulates metabolic functions throughout the body, such as converting glucose into usable energy. Unlike most Peptides, which are encoded by nuclear DNA, MOTS-c is encoded by mitochondrial DNA.
Why Buy MOTS-c Peptide from Sarmsamerica?
If you’re looking to buy MOTS-c Peptides online, there are plenty of options available. However, not all companies offering MOTS-c for sale are equally trustworthy.
To buy MOTS-c from a randomly selected website can be risky (even if the price seems reasonable) because you can’t be certain about their quality-control processes, especially if they do not have third-party certificates available.
At Sarmsamerica, you can find the highest quality MOTS-c for sale anywhere on the internet.
When you buy Peptides from Sarmsamerica, you are choosing the highest quality products. Our pure compounds are tested and certified by accredited American third-party labs, and these labs accept phone calls to verify the validity of their certificates.
Our products are lyophilized in glass vials and stored refrigerated to maintain potency. We operate a transparent business, avoiding discreet payment methods and ensuring no misrepresentation of our products. Explore the highest quality online.
For orders over $160, we offer free shipping. Need your items fast? We also provide express shipping services. Plus, sign up for our newsletter to receive a 10% discount.
If you have any questions about our MOTS-C or other products, please feel free to contact us, and we will respond as soon as possible.
References:
- Kim SJ, Miller B, Mehta HH, Xiao J, Wan J, Arpawong TE, Yen K, Cohen P. The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity. J Physiol Rep. 2019Jul;7(13):e14171. doi: 10.14814/phy2.14171. PMID: 31293078; PMCID: PMC6640593.
- Crescenzo R, Bianco F, Mazzoli A, Giacco A, Liverini G, Iossa S. A possible link between hepatic mitochondrial dysfunction and diet-induced insulin resistance. Eur J Nutr. 2016Feb;55(1):1-6. doi: 10.1007/s00394-015-1073-0. PMID: 26476631.
- Lu H, Wei M, Zhai Y, Li Q, Ye Z, Wang L, Luo W, Chen J, Lu Z. MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction. J Mol Med (Berl). 2019 Apr;97(4):473-485. doi: 10.1007/s00109-018-01738-w. Epub 2019Feb 6. PMID: 30725119.
- Lee C, Kim KH, Cohen P. MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism. Free Radic Biol Med. 2016 Nov;100:182-187. doi: 10.1016/j.freeradbiomed.2016.05.015. Epub 2016May 20. PMID: 27216708; PMCID: PMC5116416.
- Kim KH, Son JM, Benayoun BA, Lee C. The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress. Cell Metab. 2018Sep 4;28(3):516-524.e7. doi: 10.1016/j.cmet.2018.06.008. Epub 2018 Jul 5. PMID: 29983246; PMCID: PMC6185997.
- Che N, Qiu W, Wang JK, Sun XX, Xu LX, Liu R, Gu L. MOTS-c improves osteoporosis by promoting the synthesis of type I collagen in osteoblasts via TGF-β/SMAD signaling pathway. Eur Rev MedPharmacol Sci. 2019Apr;23(8):3183-3189. doi: 10.26355/eurrev_201904_17676. PMID: 31081069.
- Hu BT, Chen WZ. MOTS-c improves osteoporosis by promoting osteogenic differentiation of bone marrow mesenchymal stem cells via TGF-β/Smad pathway. Eur Rev Med Pharmacol Sci. 2018Nov;22(21):7156-7163. doi: 10.26355/eurrev_201811_16247. PMID: 30468456.
- Fuku N, Pareja-Galeano H, Zempo H, Alis R, Arai Y, Lucia A, Hirose N. The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity? Aging Cell. 2015Dec;14(6):921-3. doi: 10.1111/acel.12389. Epub 2015 Aug 20. PMID: 26289118; PMCID: PMC4693465.
- Qin Q, Delrio S, Wan J, Jay Widmer R, Cohen P, Lerman LO, Lerman A. Downregulation of circulating MOTS-c levels in patients with coronary endothelial dysfunction. Int J Cardiol. 2018Mar 1;254:23-27. doi: 10.1016/j.ijcard.2017.12.001. Epub 2017 Dec 6. PMID: 29242099.
- Zheng Y, Wei Z, Wang T. MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation. Front Endocrinol (Lausanne). 2023Jan 25;14:1120533. doi: 10.3389/fendo.2023.1120533. PMID: 36761202; PMCID: PMC9905433.
- Reynolds, J.C., Lai, R.W., Woodhead, J.S.T. et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun 12, 470 (2021).https://doi.org/10.1038/s41467-020-20790-0
- Mots-C Peptide: Exploring its Potential in Health and Longevity. Peptide Information(2023).
Disclaimer: This preparation is for in vitro laboratory research purposes only by licensed professionals and is not approved by the FDA for any bodily introduction into humans or animals.
MOTS-c is not a compound, food, supplement, or cosmetic and may not be misbranded, misused, or mislabeled as such.
