Description
YK11 is not difficult to find as a SARM for sale online, but only Sarmsamerica offers genuine, high-quality YK11 SARM. As your trusted source for SARMs, Sarmsamerica ensures the highest quality and potency available. Research indicates that YK-11 is a myostatin inhibitor, attaching to muscle and bone tissue without affecting internal organs. Due to its myostatin-inhibiting properties, most individuals experience muscle cell growth when using YK 11. Additionally, research reports attribute increased levels of follistatin to this well-known SARM.
High-Quality YK 11 for Sale
YK 11, one of the newest SARMs available for sale, functions as a gene-specific agonist of the androgen receptor (AR) in MDA-MB 453 cells. It operates on various anabolic pathways, demonstrating greater anabolic activity in vitro in C2C12 myoblasts than in DHT. YK 11 has been shown to promote a cascade of muscle growth and key myogenic regulatory factors in skeletal muscle tissue, such as myogenic differentiation factor (MyoD) and myogenic factor 5 (Myf5), to a significantly greater extent than DHT.
This partially explains why YK11 selectively modulates the AR. Unlike testosterone and most other AR-mediated anabolic agents, YK11 is orally bioavailable, eliminating the need for injections for proper absorption. Currently, YK-11 is intended for laboratory research use only, and its side effects are not fully known.
YK11 and Muscle Growth
What truly distinguishes YK11 is its anabolic activity, which is significantly modulated by the expression of follistatin. Researchers discovered this by co-administering anti-follistatin antibodies with YK11 to observe the difference in effects. Follistatin has been shown to promote insulin-stimulated glucose and amino acid uptake into skeletal muscle cells, directly improving insulin sensitivity and increasing skeletal muscle mass. Additionally, follistatin proteins block inhibitory ligands from binding to Transforming Growth Factor-ß.
Follistatin Effects on Muscle Tissue
Perhaps the most appealing effect of follistatin is its ability to bind and neutralize catabolic proteins such as Activin A, Activin B, and Myostatin. Unfortunately, follistatin proteins undergo rapid proteolysis and have limited bioavailability and half-life, even when injected directly into the muscle. However, YK-11 stimulates the body to produce more follistatin proteins both systemically and locally, potentially overcoming the limitations of direct follistatin administration and promoting muscle growth.
YK 11 for Muscle Wasting
Animal studies have explored the potential of YK 11 as a treatment for sepsis-induced muscle wasting. Researchers observed protective effects on muscle and organ tissue and suppression of gram-negative bacteria-induced cytokine inflammation. In eight-week-old septic mice treated with YK 11, the mortality rate significantly decreased. The researchers concluded that this effect was due to the suppression of myostatin and an increase in the expression of the follistatin gene.
YK11 and Bone growth
YK11, when combined with dihydrotestosterone (DHT), was found to accelerate cell proliferation and mineralization in MC3T3-E1 mouse osteoblast cells. Treatment with YK11 also induced the expression of osteoblast-specific differentiation markers, such as osteoprotegerin and osteocalcin, compared to untreated cells. These effects were diminished by treatment with an androgen receptor (AR) antagonist, indicating that the androgen receptor mediates the observed results.
Mechanisms for Bone Recovery
Investigations into the mechanisms of YK11’s action on the AR revealed that it activates non-genomic signaling via phosphorylation of the Akt protein. This signaling pathway is a key regulator of androgen-mediated osteoblast differentiation, positioning YK11 as a promising candidate for future research in bone tissue engineering.
Potential Research Findings with This Stack
1. Muscle Growth
- RAD 140 (Testolone): Research suggests RAD-140 may exhibit potent anabolic properties, leading to significant increases in muscle mass in experimental settings.
- YK11: Shown to promote muscle hypertrophy by increasing follistatin levels, which inhibits myostatin and enhances anabolic activity.
- LGD-4033 (Ligandrol): Demonstrates strong anabolic effects, leading to measurable gains in lean muscle mass in preclinical studies.
- MK677 (Ibutamoren): Stimulates growth hormone and IGF-1 levels, which are associated with muscle growth and improved recovery.
2. Strength Enhancement
- RAD 140 and YK-11: Research highlights their ability to increase strength and power by activating androgen receptors in muscle tissues.
- LGD-4033: Preclinical trials have shown its anabolic activity may contribute to improved strength.
3. Fat Loss
- RAD 140 and LGD-4033: Both have been shown in research to promote fat loss by enhancing metabolic rate and supporting the development of lean muscle mass.
- MK677: Improves body composition by increasing growth hormone levels, which may aid in reducing fat mass.
4. Bone Density and Health
- YK11 and LGD-4033: Studies indicate their potential to improve bone mineral density and support skeletal strength by targeting androgen receptors in bone tissues.
- MK677: Enhances bone density by increasing growth hormone secretion, which supports bone health and mineralization.
5. Recovery and Healing
- MK677: Known to accelerate recovery and healing by boosting growth hormone and IGF-1 levels, which facilitate tissue repair.
- RAD 140 and LGD-4033: Show potential in reducing muscle soreness and shortening recovery times in experimental models.
6. Overall Performance
- RAD 140, YK11, and LGD-4033: Combined, these compounds may improve endurance, stamina, and overall performance, based on findings in preclinical studies.
- MK677: Contributes to better energy levels and improved sleep quality, which can positively influence performance in research settings.
Important Research Considerations
- Experimental Use Only:
- All compounds mentioned, including RAD- 40, YK11, LGD-4033, and MK677, are classified as experimental substances and are not approved for human use by regulatory authorities like the FDA.
- Long-Term Safety:
- While preclinical studies provide valuable insights, long-term effects and safety profiles remain unclear, highlighting the need for further research.
- Ethical Research Practices:
- Researchers must adhere to ethical standards and regulatory guidelines when conducting studies involving these compounds.
Disclaimer
This information is intended for educational and research purposes only. The compounds discussed are experimental and should be used solely within the context of preclinical or clinical research under the supervision of qualified professionals.
YK11 Side Effects
Side effects of YK11 SARM are uncommon, but some users have reported mild acne, increased aggression, and joint pain. While these side effects are generally mild, it is advisable to seek medical attention if they persist or worsen. Rare cases of liver damage have been reported, which can be mitigated by using a liver support product. It is also recommended to undergo post-cycle therapy with either tamoxifen or clomiphene for four weeks after completing a cycle of YK11.
Recap of Side Effects:
- Mild Acne
- Joint Pain
- Reversible Liver Impairment
- Increased Aggression
YK11 Clinical Dose Information
Studies for research purposes mentioned, that due to the potency of YK11 SARMs, higher dosages are unnecessary to achieve efficacy. YK11 has a known half-life of twelve hours, allowing for two effective dosing methods. One approach is to take it twice daily at 5mg per dose or a single dose of 10mg per day.
Because YK11 can cause reversible testosterone suppression, it’s crucial to complete post-cycle therapy (PCT) after each cycle. The recommended PCT regimen should last four weeks and can include either tamoxifen or clomiphene. Tamoxifen is generally the more popular choice. For PCT, a tamoxifen dose between 25mg and 50mg is recommended, starting on the higher side and gradually reducing as you progress through your PCT.
Popular Stacks with YK 11
If you are considering stacking, there are a few effective variations with YK 11. For a simpler approach, you can pair YK 11 with LGD-4033. Unlike most stacks, this combination only requires a duration of six weeks.
The stack works with the following doses:
Week 1 & 2
- LGD-4033: 10mg per day
- YK11: 10mg per day
Week 3 thru 6
- LGD 4033: 20mg per day
- YK11: 10mg per day
In a more complex stack, you can take both LGD-4033, YK11, and MK677 together for an eight-week cycle with the following dosages.
Week 1
- LGD-4033: 5mg per day
- YK11: 5mg per day
- MK677: 25mg per day
Week 2 thru 5
- LGD-4033: 10mg per day
- YK11: 10mg per day
- MK677: 25mg per day
Week 6 thru 8
- LGD-4033: 15mg per day
- YK11: 20mg per day
- MK677: 25mg per day
The advantage of this stack is that incorporating MK677 provides additional benefits, such as improved memory, alongside increased muscle mass. However, if MK677 isn’t suitable for you, you can still combine LGD-4033 and YK11 SARMs with S4 Andarine. The structure of this stack is as follows:
Week 1
- LGD-4033: 10mg per day
- YK11: 10mg per day
- S4 Andarine: 50mg per day
Week 2 thru 8
- LGD-4033: 20mg per day
- YK11: 10mg per day
- S4 Andarine: 50mg per day
In this stack, all three SARMs are recognized for enhancing muscle mass, bone density, and more! The synergy between these three makes it an excellent bulking and powerlifting stack. From these combinations, you can anticipate quicker muscle gains, improved recovery times, and additional benefits as each SARM contributes its unique advantages to the stack.
Data on our YK-11 for sale
| CAS Number: |
1370003-76-1 |
| Formula: |
C25H34O6 |
| Molar Mass: |
430.541 g/mol |
| Class: |
Myostatin Inhibitor, Selective Androgen Receptor Modulator |
| Storage: |
Store in a cool dry place away from direct sunlight to maximize shelf life.
|
This product is intended solely for laboratory research and is not approved by the FDA for human consumption. YK-11 IS NOT A DIETARY OR SPORTS SUPPLEMENT.
YK11 FAQs
What is YK11?
YK11 binds to the androgen receptor, helping to inhibit the production of myostatin in muscle tissue. This inhibition allows the muscle to produce more follistatin (FST), thereby promoting increased muscle growth.
Does YK11 suppress testosterone?
Similar to other SARMs, lab-tested YK11 has a dose-dependent reductive effect on natural testosterone levels in males.
Does YK11 function as a myostatin inhibitor?
Data shows that YK11 suppresses myostatin through the modulation of the follistatin pathway. This mechanism allows for increased muscle growth by inhibiting the muscle growth-restricting effects of myostatin.
Does YK11 improve bone growth?
Studies suggest that YK11 induces the expression of osteoblast-specific differentiation markers, such as osteoprotegerin and osteocalcin, potentially aiding in bone tissue production.
Does YK11 burn fat?
In animal studies, YK11 was shown to increase bone density and overall bone health. It also led to increased muscle mass and strength while reducing fat mass.
Why is Sarmsamerica the best place to buy YK-11 online?
YK-11 is highly sought after by researchers for its activity in both the traditional androgen-mediated growth pathway and the follistatin pathway. While YK-11 is not difficult to find as a SARMs for sale online, Sarmsamerica is the premier source to buy YK-11 online due to our consistent, verifiable high quality, fast shipping, safer bottling and packaging, and exceptional customer service. Additionally, our YK-11 is available in our Sarms Stack (Mass Building Stack).
At Sarmsamerica, you can find the highest quality YK-11 for sale anywhere on the internet. When you buy SARMs from us, you are choosing top-tier ingredients. Our compounds are a minimum of 98% pure, tested and certified by accredited American third-party labs, suspended in USP grade (the highest grade) PEG400, and bottled in America.
We operate a transparent business with no need for discreet payment methods and no misrepresentation of our products. We offer only the highest quality research chemicals available online. We provide free shipping on orders over $160 and offer express shipping for those requiring expedited delivery. Additionally, customers who subscribe to our email list receive a 10% discount.
That’s why we confidently claim to offer the best YK 11 for sale on the market today. If you have any questions about our capsules YK11 products, please contact us, and we’ll respond as soon as possible.
Abuse Warning
YK11 is an investigational compound still awaiting FDA approval and is not a dietary supplement. At Sarmsamerica, we are chemical suppliers specializing in sourcing and quality control, not medical doctors. We do not encourage or condone consumer use of SARM products; they are intended for research purposes only.
SARMs should only be used under the supervision and direction of a medical doctor or designated research authority. We strongly discourage the use of SARMs for performance enhancement in sports and bodybuilding and caution against relying on “bro science” and peer consensus when making decisions about human health.
Scientific References:
- Kanno Y, Hikosaka R, Zhang SY, Inoue Y, Nakahama T, Kato K, Yamaguchi A, Tominaga N, Kohra S, Arizono K, Inouye Y (2011). “(17α,20E)-17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester (YK11) is a partial agonist of the androgen receptor”. Biological & Pharmaceutical Bulletin. 34 (3): 318–23. PMID 21372378
- Kanno Y, Ota R, Someya K, Kusakabe T, Kato K, Inouye Y (2013). “Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression”. Biological & Pharmaceutical Bulletin.36 (9): 1460–5. PMID 23995658.
- Han X, Moller LLV, et al. Mechanisms involved in follistatin-induced hypertrophy and increased insulin action in skeletal muscle. J Cachexia Sarcopenia Muscle. 2019Aug 11. doi: 10.1002/jcsm.12474
- Castonguay R, Lachey J, Wallner S, et al. Follistatin-288-Fc Fusion Protein Promotes Localized Growth of Skeletal Muscle. J Pharmacol Exp Ther. 2019Mar;368(3):435-445. doi: 10.1124/jpet.118.252304. Epub 2018 Dec 18.
- Lee SJ, Gharbi A, Shin JE, Jung ID, Park YM. Myostatin inhibitor YK11 as a preventative health supplement for bacterial sepsis. Biochem Biophys Res Commun. 2021 Mar 5;543:1-7. doi: 10.1016/j.bbrc.2021.01.030.Epub 2021 Feb 12. PMID: 33588136.
- Yatsu T, Kusakabe T, Kato K, Inouye Y, Nemoto K, Kanno Y. Selective Androgen Receptor Modulator, YK11, Up-Regulates Osteoblastic Proliferation and Differentiation in MC3T3-E1 Cells. Biol Pharm Bull.2018;41(3):394-398. doi: 10.1248/bpb.b17-00748. PMID: 29491216
- https://www.jstage.jst.go.jp/article/bpb/36/9/36_b13-00231/_article
- https://pubmed.ncbi.nlm.nih.gov/33588136/
- https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/rcm.7886
- https://pubmed.ncbi.nlm.nih.gov/23995658/
