SELANK 5MG

Description

Clinical studies on Selank demonstrate its potential for treating anxiety disorders. At Sarmsamerica, we offer certified, high-quality Selank for sale in 10mg vials. Research on animal studies has shown that Selank can restore adrenaline, norepinephrine, and dopamine functions.

Selank: A Synthetic Peptide with Demonstrated Research-based Benefits

Selank is a synthetic Peptide, similar to the naturally occurring Tuftsin, and is capable of modifying or regulating immune functions. However, Selank is more stable and has a longer half-life.

Research shows that Selank not only helps individuals with generalized anxiety disorder but can also:

• Lower stress levels
• Improve mood
• Promote memory retention and learning

Selank has a sedative effect similar to benzodiazepines; however, it is not habit-forming and does not cause withdrawal or amnesia.

Selank – What You Need to Know

Selank, developed by the Institute of Genetics of the Russian Academy of Sciences, is considered both a nootropic and a Peptide due to its anxiolytic and cognitive-enhancing properties.

The Russian Academy of Sciences combined tuftsin, a naturally occurring immunomodulatory Peptide, with a stabilizing compound. This resulted in the creation of a synthetic variation of the Peptide with a longer half-life and improved metabolic stability compared to its predecessor.

Selank Molecule

Selank Modulation of GABA Signaling Genes

Research in rats shows that Selank modulates GABA signaling genes by increasing the binding affinity of the GABA receptor. By doing this, Selank can alter the expression of nerve cell genes in the nervous system.

Comparison of Selank with Benzodiazepines in Anxiety Disorders

Selank and benzodiazepines exhibit similar effects on anxiety disorders, as observed in a recent study conducted on rats. Selank has a slight advantage over benzodiazepines in addressing high anxiety levels. However, when used sequentially, the two treatments together show the best results for treating chronic mild stress that is unpredictable.

Selank and Inhibition of Enzyme Breakdown and Enkephalin Protection

Selank’s effects are likely due to its ability to inhibit the enzyme that breaks down circulating enkephalins and other Peptides. People with anxiety and phobic disorders produce more of these enzymes, resulting in shorter half-lives for enkephalins in their bloodstream during anxiety episodes.

By resetting this enzymatic pathway, Selank may protect the body’s natural anxiolytic Peptides. Research in anxiety-prone mice indicates that some of Selank’s effects are due to the prevention of enkephalin degradation.

Anti-Inflammatory Effects and Depression Treatment with Selank

In patients with depression, Selank can suppress the gene responsible for producing an inflammatory cytokine. This gene suppression is not observed in healthy individuals and is only noted in patients with depression.

Selank may treat anxiety-related symptoms such as:

• Tiredness
• Headache
• Heart palpitations
• Increased blood pressure
• Nerve pain
• Depression

Both Benzodiazepines and Selank show similar benefits in reducing anxiety, but Selank additionally helps to reduce fatigue and pain.

Selank and Chronic Fatigue

The effect on pain and fatigue may be due to Selank’s ability to slow the breakdown of enkephalins, the body’s natural painkillers. In tests on rats, Selank was shown to regulate the expression of genes affecting chemokines, cytokines, and their receptors, which are involved in the body’s inflammatory processes.

Selank has specifically been found to alter the expression of the BcI6 gene, which is primarily involved in the development of the immune system. Further testing showed that Selank temporarily changes the expression of the C3, CAsp1, Il2rf, and Xcr1 genes in the mouse spleen. By affecting these genes, Selank can change the balance of the immune system and modulate inflammation.

Memory and Anxiety Changes

Increased anxiety makes it challenging for the body to store new information and recall memories. While anxiety medication can alleviate the negative impact of anxiety on learning and memory, Selank appears to directly enhance cognition. Research in rats shows that Selank improves the stability of trace memory, thereby increasing the efficiency of memory storage, irrespective of the rats’ anxiety levels.

Selank Gene Expression Effects

Selank can do more than simply reduce stress-related memory impairment. It may also enhance memory by altering the expression of genes in the hippocampus. In rats administered Selank, changes were observed in the mRNA levels of 36 different genes. Most of these genes encode proteins associated with the plasma membrane and regulate ion-dependent memory and learning processes.

Restoration of Cognitive Processes After Brain Damage

Selank can restore learning and memory after brain damage has occurred. In one study, rats treated with Selank following neurotoxin-induced brain damage showed restored cognitive processes. These restorative effects appear to be related to Selank’s ability to inhibit the catecholamine system in the brain.

Data on our Selank for sale

CAS Number:	129954-34-3
Formula:	C33H57N11O9
Sequence:	Thr-Lys-Pro-Arg-Pro-Gly-Pro
Molecular Mass:	811.9 g/mol
Class:	Hexapeptide
Storage:	Keep refrigerated upon reconstitution. Lyophilized sample in a sterile glass vial. Minimum 98% pure. 5mg Selank Peptide per vial. Diluent and laboratory supplies are not included.

Selank FAQs

What Is Selank Used For?

Selank administration has demonstrated clinical significance in improving learning, memory, cognition, anxiety, depression, immune function, and sleep in test subjects.

Is Selank Addictive?

Clinical studies have shown that Selank’s effects are similar to those of low doses of tranquilizers but without withdrawal, amnesia, or dependence.

Does Selank Work Immediately?

The expression of 22 genes was observed within three hours of Selank administration, with some changes occurring within the first hour.

Is Selank a Nootropic?

Selank is considered a nootropic and anxiolytic Peptide.

Why Buy Selank Peptide from Sarmsamerica?

If you’re looking to buy Selank Peptide, numerous options are available. However, purchasing Selank from a randomly selected company can be risky. Many Peptide vendors do not test their products, or they withhold their third-party lab certificates and contact information from customers. What might they be hiding?

At Sarmsamerica, you can find the best Selank for sale anywhere on the internet. When you buy Peptides from Sarmsamerica, you are choosing the highest quality ingredients.

The Peptides for sale at Sarmsamerica are pure compounds tested and certified by accredited American third-party labs, which accept phone calls to verify the validity of their certificates.

Our research chemicals are lyophilized in glass vials and stored refrigerated to maintain potency. We operate a transparent business, avoiding discreet payment methods and ensuring no misrepresentation of our products. Explore the highest quality online.

Sarmsamerica is the best place to buy Selank online due to our consistent, verifiable high-quality products, safe bottling and packaging, fast shipping, and excellent customer service. For orders over $160, we offer free shipping. Need your items fast? We also provide express shipping services. Plus, sign up for our newsletter to get a 10% discount.

If you have any questions about our Selank or other products, please feel free to contact us, and we will respond as soon as possible.

References:

1. Volkova A, Shadrina M, Kolomin T, Andreeva L, Limborska S, Myasoedov N, Slominsky P. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Front Pharmacol.2016 Feb 18;7:31. doi: 10.3389/fphar.2016.00031. PMID: 26924987; PMCID: PMC4757669.
2. Kasian A, Kolomin T, Andreeva L, Bondarenko E, Myasoedov N, Slominsky P, Shadrina M. Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats. Behav Neurol.2017;2017:5091027. doi: 10.1155/2017/5091027. Epub 2017 Feb 9. PMID: 28280289; PMCID: PMC5322660.
3. Zozulya AA, Kost NV, Yu Sokolov O, Gabaeva MV, Grivennikov IA, Andreeva LN, Zolotarev YA, Ivanov SV, Andryushchenko AV, Myasoedov NF, Smulevich AB. The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity. Bull Exp Biol Med. 2001Apr;131(4):315-7. doi: 10.1023/a:1017979514274. PMID: 11550013.
4. Sokolov OY, Meshavkin VK, Kost NV, Zozulya AA. Effects of Selank on behavioral reactions and activities of plasma enkephalin-degrading enzymes in mice with different phenotypes of emotional and stress reactions. Bull Exp Biol Med. 2002Feb;133(2):133-5. doi: 10.1023/a:1015582302311. PMID: 12432865.
5. Uchakina ON, Uchakin PN, Miasoedov NF, Andreeva LA, Shcherbenko VE, Mezentseva MV, Gabaeva MV, Sokolov OIu, Zozulia AA, Ershov FI. [Immunomodulatory effects of selank in patients with anxiety-asthenic disorders]. Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(5):71-5. Russian.PMID: 18577961.
6. Zozulia AA, Neznamov GG, Siuniakov TS, Kost NV, Gabaeva MV, Sokolov OIu, Serebriakova EV, Siranchieva OA, Andriushenko AV, Telesheva ES, Siuniakov SA, Smulevich AB, Miasoedov NF, Seredenin SB. [Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia]. Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(4):38-48. Russian. PMID: 18454096.
7. Kolomin T, Shadrina M, Andreeva L, Slominsky P, Limborska S, Myasoedov N. Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank. Regul Pept. 2011Oct 10;170(1-3):18-23. doi: 10.1016/j.regpep.2011.05.001. Epub 2011 May 24. PMID: 21609736.
8. Agapova TIu, Agniullin IaV, Silachev DN, Shadrina MI, Slominskiĭ PA, Shram SI, Limborskaia SA, Miasoedov NF. [Effect of semax on the temporary dynamics of brain-derived neurotrophic factor and nerve growth factor gene expression in the rat hippocampus and frontal cortex]. Mol Gen Mikrobiol Virusol.2008;(3):28-32. Russian. PMID: 18756821.
9. Semenova TP, Kozlovskiĭ II, Zakharova NM, Kozlovskaia MM. [Experimental optimization of learning and memory processes by selank]. Eksp Klin Farmakol.2010 Aug;73(8):2-5. Russian. PMID: 20919548.
10. Semenova TP, Kozlovskaya MM, Zakharova NM, Kozlovskii II, Zuikov AV. Effect of selank on cognitive processes after damage inflicted to the cerebral catecholamine system during early ontogeny. Bull Exp Biol Med.2007 Nov;144(5):689-91. doi: 10.1007/s10517-007-0406-2. PMID: 18683497.
11. Kost NV, Sokolov OIu, Gabaeva MV, Grivennikov IA, Andreeva LA, Miasoedov NF, Zozulia AA. Ingibiruiushchee deĭstvie semaksa i selanka na énkefalindegradiruiushchie fermenty syvorotki krovi cheloveka [Semax and selank inhibit the enkephalin-degrading enzymes from human serum]]. Bioorg Khim. 2001May-Jun;27(3):180-3. Russian. doi: 10.1023/a:1011373002885. PMID: 11443939.
12. Selank Peptide: Exploring its Potential in Anxiety and Cognitive Enhancement. Peptide Information(2023)