SR9009 Stenabolic SARM 10MG

Description

Sarmsamerica proudly offers the highest quality Stenabolic for sale. SR9009 (Stenabolic) acts as an agonist of the Rev-ErbA protein, which is found in several parts of the body, including the liver and the musculoskeletal system. Research has shown its effects on regulating circadian rhythms, influencing fat-storing cells, and impacting lipid and glucose metabolism in the liver. While SR9009 is not classified as a selective androgen receptor modulator (SARM), it binds to Rev-ErbA and produces effects similar to SARMs, along with additional benefits.

High Quality SR9009 for Sale

SR9009, developed in 2013 at The Scripps Research Institute (now Scripps Research), initially showed promising results in enhancing metabolic activity and promoting skeletal muscle growth in mice. Importantly, it does not impact endogenous testosterone levels. Many researchers regard SR9009 as highly effective for reducing body fat, making it a preferred choice for cutting phases. Sarmsamerica is recognized as the best place to buy Stenabolic online.

SR9009 has been studied for its potential effects in laboratory settings, including:

• Increased resting metabolic activity
• Potential cardioprotective properties
• Regulation of circadian rhythm and sleep patterns
• Enhanced endurance in experimental models
• Observations related to weight management
• Modulation of cholesterol levels
• Reduced markers of inflammation in studies
• Effects on arterial plaque management

SR9009 has demonstrated potential in conditions such as heart failure, COPD (chronic obstructive pulmonary disease), and metabolic syndrome. These findings suggest its versatility in addressing various health challenges.

More research is needed on human subjects to fully understand the potential health benefits of SR9009. Studies conducted on animals have shown promising results, indicating that SR9009 holds potential as a health-enhancing product.

SR9009 holds promise as a potential “exercise in a bottle,” though it has not yet received official approval from the Food and Drug Administration (FDA) for human use. Therefore, it should currently be regarded solely for laboratory research purposes and not as a supplement for aerobic exercise.

SR9009 and Circadian Rhythm

Synthetic REV-ERB ligands, such as SR9009, have been demonstrated to modify circadian behavior in mice and influence the circadian expression patterns of core clock genes in the hypothalamus. These ligands also affect metabolic genes in tissues like the liver, skeletal muscle, and adipose tissue, resulting in increased energy expenditure.

Administration of a REV-ERB agonist to diet-induced obese mice led to a decrease in obesity characterized by reduced fat mass, along with significant improvements in dyslipidemia and hyperglycemia. These findings suggest that synthetic REV-ERB ligands targeting the circadian rhythm could potentially benefit the treatment of both sleep disorders and metabolic diseases.

SR 9009 and Energy Metabolism

Administration of the REV-ERBα agonist SR9009 has been demonstrated to impact energy homeostasis in animals. A study on goldfish revealed that SR9009 inhibited feeding behavior, resulting in decreased body weight and length gain. Furthermore, the study found that SR9009 lowered the abundance of ghrelin mRNA in the intestine, while increasing the expression of leptin-aI in the liver.

SR9009 has also been observed to decrease plasma glucose levels, accompanied by increased glycolysis and reduced gluconeogenesis rates in the liver. Additionally, lipid levels and activities of lipogenic enzymes were lowered. Interestingly, locomotor activity did not affect energy expenditure. These findings collectively suggest that activation of REV-ERBα by SR9009 promotes a negative energy balance by reducing energy inputs and regulating lipid and glucose metabolism.

SR9009 and Endurance

In a 2013 study, mice administered with SR9009 were found to exhibit enhanced endurance capabilities, allowing them to run longer distances and for extended durations compared to normal mice.

Overexpression of Rev-erb-α in vitro has been demonstrated to enhance mitochondrial biogenesis and improve mitochondrial respiratory capacity. This mechanism differs from how cardarine increases endurance. Moreover, both overexpression and pharmacological activation of Rev-erb-α in vivo have shown to increase exercise capacity. These findings suggest that targeting Rev-erb-α pharmacologically may potentially enhance muscle oxidative function by regulating gene networks involved in mitochondrial quantity and performance.

SR9009 and Cardio protection

Research conducted on REV-ERB deficient mice indicated significant cardiac myopathy following transverse aortic constriction compared to wild-type control mice, highlighting the protective role of REV-ERB in the heart under pressure overload conditions. Interestingly, SR9009 demonstrated cardioprotective effects even in REV-ERBα/β cardiac-specific double knockout (cDKO) mice.

SR9009 demonstrated consistent cardioprotective effects whether administered during peak or trough REV-ERB expression, indicating additional mechanisms beyond REV-ERB. These results underscore the role of REV-ERB in mitigating adverse cardiac remodeling under pressure overload conditions, with SR9009 offering independent cardioprotective benefits in such scenarios.

SR 9009 and the Lungs

In vitro experiments have shown that SR9009 can activate Rev-Erbα pharmacologically, leading to a reduction in the inflammatory response during lung injury by inhibiting TLR4-induced NF-κB activation. SR9009 treatment has also been effective in improving metabolic parameters, including ameliorating acidosis and hypoxemia by increasing arterial PaO2, SO2, HCO3-, and blood pH, while reducing arterial PaCO2 and lactic acid concentration. These findings highlight the potential of SR9009 in mitigating sepsis-induced lung injury and suggest that targeting Rev-Erbα could be a promising therapeutic approach for preventing and managing acute lung injury.

Cellular research has explored the anti-tumor properties of SR9009 specifically in lung cancer. Studies have demonstrated that SR9009 exhibits lethality against both chemosensitive and chemoresistant small cell lung cancer (SCLC) cells. This effect is mediated in part by REV-ERBα, which plays a role in SR9009’s antitumor activity. Furthermore, the core autophagy gene Atg5 has been identified as a direct downstream target of REV-ERBα, and its suppression by the REV-ERB agonist inhibits autophagy activity. This interaction ultimately contributes to SR9009-induced cytotoxicity in SCLC cells.

Understanding SR9009 Preclinical Studies and Findings

SR9009 offers a range of benefits supported by both animal testing and anecdotal evidence from bodybuilders and fitness enthusiasts. These benefits include weight loss, improvements in blood cholesterol levels, reduced anxiety, and decreased inflammation. These effects make SR9009 a potentially valuable compound in both research and athletic performance contexts.

Scientific Findings on SR9009:

1. Potential improvements in endurance and energy metabolism observed in experimental models
2. Possible effects on fat metabolism and body composition under investigation
3. Observed muscle mass preservation and growth in preclinical studies
4. Research findings suggest modulation of lipid storage and metabolism

Sr9009 Stenabolic Molecule

Data on Our SR9009 for Sale

This product is intended solely for laboratory research and has not been approved by the FDA for human consumption. SR9009/Stenabolic is NOT to be used as a dietary or sports supplement.

SR9009 FAQs

What is SR9009 good for?

Research is being conducted on SR9009 to explore its potential effects on circadian rhythm regulation, sleep quality improvement, fat burning enhancement, and cardiac health support.

Does SR9009 burn fat?

Studies indicate that SR9009 may enhance metabolic rate, boost fat burning, and regulate circadian rhythm.

Does SR9009 lower testosterone?

Currently, there is no evidence indicating that SR9009 administration suppresses natural testosterone levels.

Does SR9009 affect sleep?

SR9009 regulates circadian rhythm and may enhance sleep quality and timing, though further research is required.

Is SR9009 good for heart?

In mouse models, administering SR9009 shortly after a heart attack reduced inflammation and scarring, facilitating better heart repair. The researchers published these findings in Nature Communications Biology. SR9009 works by disrupting genes that typically activate immune responses following a heart attack.

Why is Sarmsamerica the best place to buy SR9009 online?

Many sites offer SARMs for sale, but Sarmsamerica stands out as the best source to buy SR9009 online due to their consistent, verifiable quality, safer bottling and packaging, and exceptional customer service. Our SR-9009 is also available in pure powder form. While there are numerous websites offering Stenabolic for sale, not all sellers are equally reputable. It’s challenging to ensure the quality of products from some of these unknown sites, or to know how they will handle your personal information.

When you buy SARMs from Sarmsamerica, you are opting for the highest quality ingredients. Our compounds are a minimum of 98% pure, tested and certified by accredited American third-party labs. They are suspended in USP grade PEG400, the highest grade available, and bottled in America. Our products are packaged in glass bottles with fixed glass droppers to prevent the leaching of unwanted plasticizers such as BPA and to avoid contamination from external measuring tools.

We operate with full transparency, offering the highest quality research chemicals available online without the need for discreet payment methods or product misrepresentation. Enjoy free USPS shipping on orders over $160, and express shipping options for urgent needs. Additionally, customers who sign up for our email list receive a 10% discount.

We are committed to ensuring customer satisfaction. Feel free to contact us with any questions, and we will respond promptly.

Abuse Warning

SR9009 is an investigational compound awaiting FDA approval and is not a dietary supplement. At Sarmsamerica, we are chemical suppliers specializing in sourcing and quality control, not medical professionals. We do not encourage or condone consumer use of SARMs products; they are intended for research purposes only.

SARMs should only be used under the supervision and direction of a medical doctor or designated research authority. We strongly discourage using SARMs for performance enhancement in sports and bodybuilding and caution against relying on “bro science” and peer consensus for decisions about human health.

Scientific References:

1. Solt, L., Wang, Y., Banerjee, S. et al.Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature 485, 62–68 (2012).
2. Woldt, E., Sebti, Y., Solt, L. et al.Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy. Nat Med 19, 1039–1046 (2013).
3. Li H, Song S, Tien CL, Qi L, Graves A, Nasiotis E, Burris TP, Zhao Y, Sun Z, Zhang L. SR9009 improves heart function after pressure overload independent of cardiac REV-ERB. Front Cardiovasc Med. 2022Jul 14;9:952114. doi: 10.3389/fcvm.2022.952114.
4. Hu M, Zhang L, Cao J, Jiang Y, Liu G. SR9009 Regulates Acute Lung Injury in Mice Induced by Sepsis. Can Respir J. 2022Jul 1;2022:5802938. doi: 10.1155/2022/5802938. PMID: 35814267; PMCID: PMC9270156.
5. Shen W, Zhang W, Ye W, Wang H, Zhang Q, Shen J, Hong Q, Li X, Wen G, Wei T, Zhang J. SR9009 induces a REV-ERB dependent anti-small-cell lung cancer effect through inhibition of autophagy. Theranostics. 2020Mar 15;10(10):4466-4480. doi: 10.7150/thno.42478. PMID: 32292508; PMCID: PMC7150483.
6. Saiz N, Herrera-Castillo L, Isorna E, Delgado MJ, Conde-Sieira M, Soengas JL, de Pedro N. REV-ERBα Agonist SR9009 Promotes a Negative Energy Balance in Goldfish. Int J Mol Sci. 2022Mar 8;23(6):2921. doi: 10.3390/ijms23062921. PMID: 35328345; PMCID: PMC8955992.
7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150483/
8. https://pubmed.ncbi.nlm.nih.gov/22460951/
9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737409/
10. https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/dta.2538