BUY RAD140 Testolone 15MG

Description

Sarmsamerica offers premium-quality Testolone RAD 140, meticulously crafted for researchers seeking the highest standards of potency and purity. Known scientifically as RAD140, Testolone stands out as a selective androgen receptor modulator (SARM), offering similar benefits to anabolic steroids without the associated risks. Its potential applications include research into muscle wasting and osteoporosis treatment, with ongoing studies exploring its potential to replace testosterone replacement therapy (TRT) while minimizing adverse effects. Furthermore, RAD140 has shown promise in enhancing stamina and promoting fat loss, making it a valuable focus of scientific investigation.

High-Quality RAD 140 for Sale

RAD 140, commonly referred to as Testolone, belongs to the category of selective androgen receptor modulators (SARMs). Originally conceived as a prospective substitute for testosterone replacement therapy, RAD 140 should not be mistaken for its esterified counterpart, RAD 150, also recognized as TLB 150.

RAD140 selectively binds to androgen receptors (AR), distinguishing itself by not eliciting the comprehensive spectrum of androgenic effects associated with substances such as testosterone, DHT, or anabolic steroids.

What Is RAD 140?

As previously mentioned, RAD140 is classified as a SARM, distinguishing it as the closest compound to an anabolic steroid without falling into that category. SARMs, being selective in nature, specifically target muscles and bone tissues, thereby minimizing potential damage to vital organs. RAD 140, for instance, is frequently explored as a treatment for conditions such as muscle wasting and osteoporosis.

High AR Binding Affinity of RAD 140

RAD140 has shown remarkable affinity for the androgen receptor (AR), with a Ki value of 7 nM, surpassing that of DHT and most anabolic steroids. For comparison, recent preclinical models indicate testosterone has an affinity of 29 nM for the androgen receptor (AR), while DHT has an affinity of 10 nM.

Unlike testosterone and many other androgen receptor-mediated anabolic agents, Testolone (RAD140) is orally bioavailable. This means it can be effectively absorbed without the need for injections. It is widely regarded by researchers as one of the premier SARMs for bulking and increasing lean body mass.

Testolone (RAD140) is a relatively recent addition to the lineup of SARMs for sale. Originally developed in 2010 with a focus on potential treatments for osteoporosis and muscle gains, recent studies involving rats, primates, and clinical trials have suggested it may offer further therapeutic benefits.

RAD 140 and Its Potential in Muscle Growth Research

A study conducted on young male cynomolgus monkeys examined the anabolic effects of RAD140 over 28 days at doses of 0.01 mg/kg, 0.1 mg/kg, and 1 mg/kg per day. The results showed a mean weight gain of 10% in both the 0.1 mg/kg/day and 1 mg/kg/day groups. Interestingly, the study revealed a dose-response curve that plateaued, indicating that higher doses did not provide additional benefits beyond those achieved with lower doses.

In the study, no consistent effect on body fat mass was observed in either the 0.1 mg/kg/day or 1 mg/kg/day groups of RAD140-treated young male cynomolgus monkeys. However, there was a notable increase in muscle mass in these groups. Importantly, no significant increases in liver enzymes or prostate weight were reported, suggesting RAD140 exhibits a high degree of selectivity for androgen receptors in muscle tissue.

RAD140 and Neuroprotection

Androgens have demonstrated clinical relevance in Alzheimer’s Disease (AD) by potentially preventing neuronal apoptosis and enhancing cognitive function. This effect is primarily mediated through a non-genomic mechanism of the Androgen Receptor (AR). Rapid signaling via the phosphoinositide 3-kinase/Akt pathway, activated by androgens, regulates the expression of various proteins associated with apoptosis, including Bax, seladin 1, survivin, XIAP, and bcl-xl.

Androgens are also implicated in maintaining neuronal integrity and enhancing cognitive function. Research indicates that Aβ (beta-amyloid) disrupts synaptic structure and function in hippocampal neurons, effects that can be reversed by androgen administration. This reversal is associated with improved cognitive performance in animal models of Alzheimer’s Disease (AD). While the precise mechanisms remain incompletely understood, androgens’ ability to inhibit Aβ-induced apoptosis is believed to contribute significantly to these beneficial effects.

RAD 140 and Cellular Protection

A 2014 study explored the neuroprotective effects of RAD140 on neurons in both cultured cell models and male rats subjected to kainate-induced lesions. The research comprised two components: an in vitro investigation using cell cultures and an in vivo evaluation conducted through animal testing.

Findings from the in vitro study demonstrated that RAD140 effectively prevented cell death and restored mitochondrial membrane potential. These results suggest that RAD140 may provide neuroprotective benefits similar to those observed with testosterone and other androgens studied for their effects on neuronal health.

In the in vivo experiment, RAD140 was tested on male rats experiencing kainate-induced seizures, revealing a notable reduction in seizure activity compared to the control group. This study highlighted RAD140’s potential for providing neuroprotection, evident in both laboratory cell cultures and live animal models. These findings suggest RAD140 could potentially be explored as a treatment option for neurological disorders in the future.

RAD 140 and Dementia

Another study conducted on rats highlighted RAD140’s neuroprotective potential, suggesting it could help prevent Alzheimer’s disease and similar disorders. Additionally, RAD140 was considered potentially safer than conventional testosterone therapy. In this study, rats treated with 3 mg/kg of RAD140 showed comparable muscle tissue growth to those treated with 1 mg/kg of testosterone, but with significantly reduced androgenic activity in the prostate, indicating a favorable safety profile.

RAD-140 and Breast Cancer

In a 2017 study, researchers investigated the impact of RAD140 on breast cancer cells that expressed both androgen receptors (ARs) and estrogen receptors (ERs). The study aimed to assess RAD140’s effectiveness in inhibiting the growth of these specific breast cancer cell types.

The results of the 2017 study indicated that RAD140 effectively reduced the growth and metastasis of AR/ER+ breast cancer cells in both in vivo and in vitro models. Importantly, RAD140 achieved this without disrupting the normal cell cycle of the cancer cells. These findings suggest that RAD140 holds promise as a potential therapy for treating breast cancers that are positive for both androgen receptors and estrogen receptors.

Furthermore, the study highlighted RAD140’s distinct mechanisms of action compared to anti-estrogens and aromatase inhibitors. This differentiation suggests RAD140 could offer an alternative therapeutic strategy for hormone-sensitive breast cancers, potentially broadening the treatment options available for these conditions.

Overall, this study suggests that RAD140 holds promise as a potential treatment option for AR/ER-positive breast cancer. However, further research is necessary to fully understand its safety profile compared to established treatment methods currently in use.

RAD 140 Mechanism of Action

In vitro studies on RAD140 SARM have demonstrated a range of effects, including:

• Potential observations on weight regulation and fat metabolism in research models
• Possible effects on lean muscle development and protein synthesis under investigation
• Studies exploring beta-amyloid plaque reduction and its potential implications in neurological research
• Investigational findings on potential protective effects in breast and prostate cancer models
• Potential improvements in endurance observed in preclinical studies

It’s important to note that RAD 140 has not been confirmed by the Food and Drug Administration (FDA) for any health benefits in humans or approved for human use. It should strictly be used for laboratory research purposes only. Anecdotal reports suggest that RAD 140 administration may potentially lead to testosterone suppression and other side effects in males.

RAD 140 Research: Potential Effects and Safety Observations

RAD-140, recognized as one of the most well-known SARMs, has undergone extensive trials and research to elucidate its mechanisms and effects. Over the years, numerous benefits have been discovered. One of the primary advantages associated with RAD-140 is its potential to boost testosterone levels. Additionally, it enhances muscle mass, and stamina, and facilitates fat burning. Interestingly, RAD-140 may also offer neuroprotective properties, potentially guarding against Alzheimer’s disease.

When adhering to the correct RAD-140 dosage and staying within recommended limits, the likelihood of experiencing side effects is reduced. However, some rare side effects have been reported with RAD-140 use. These can include headaches, increased irritability, nausea, and occasionally heightened aggression. It’s important to note that many users report minimal to no side effects at all.

There are several case reports suggesting that selective androgen receptor modulators (SARMs), including RAD 140, may have the potential to cause liver injury. However, these reports typically involve small sample sizes and lack proper test controls. Like other SARMs, RAD 140 might also trigger a negative feedback loop, leading to a reduction in natural testosterone production and possibly affecting testicle size. Nonetheless, further research is required to better understand the likelihood and severity of these potential side effects.

Rad-140 Testolone Molecule

Data on our RAD 140 for sale

This preparation is strictly intended for laboratory research purposes and has not been approved by the FDA for human consumption. RAD140/Testolone is not to be considered a dietary or sports supplement.

RAD140 FAQs

Does RAD 140 suppress natural testosterone?

In a 2010 study, after 28 days of testing RAD140, it was found that testosterone levels in all three groups were suppressed to approximately 200−300 ng/dL. Although there was significant suppression noted in the 0.01 mg/kg group (p < 0.05), similar levels of suppression were observed across all groups.

Is RAD 140 safe for females?

While RAD 140 is not known to exhibit significant androgenic effects, there is limited information available regarding its safety profile in female test subjects. As such, females should exercise caution when considering participation in clinical research involving RAD 140 until more comprehensive data becomes available.

Can RAD 140 cause hair loss?

While RAD 140 itself is not typically considered highly androgenic, its administration can potentially increase free testosterone levels by releasing testosterone bound to sex hormone-binding globulin (SHBG) in the male body. This indirect effect could theoretically heighten the risk of hair loss in susceptible individuals.

What does RAD140 do to your body?

In addition to promoting muscle building, RAD-140 is also noted for its ability to aid in fat loss. By enhancing lean muscle mass, RAD-140 increases the body’s metabolic rate, which helps in more efficient fat-burning. This contributes to achieving a leaner and more defined body composition.

Is RAD140 like steroids?

RAD 140 distinguishes itself from traditional steroids due to its selectivity in targeting androgen receptors, potentially delivering desired results with fewer side effects. However, caution should still be exercised when using RAD 140. It is a potent SARM, significantly more anabolic than testosterone, which underscores the need for responsible handling and careful consideration of dosage and use.

How fast does RAD140 kick in?

The effects of RAD 140 typically become noticeable after two weeks of use.

Why is Sarmsamerica the best place to buy RAD 140 online?

A recent study analyzing 44 different products sold and marketed as SARMs on the internet revealed significant variability in quality control among companies in this industry.

In the study, findings showed that only 52% of the tested products contained the advertised SARM, while 59% had discrepancies in the amount compared to the label. Shockingly, 39% of the products contained other unapproved compounds, 25% had undisclosed substances, and 9% had no active ingredients at all. This highlights the critical importance of purchasing SARMs for research purposes only from sources that offer verified, third-party analyzed products of the highest quality.

When considering where to buy RAD 140 online, Sarmsamerica stands out as a top choice. We are known for consistently offering high-quality products that are verifiable through third-party testing. Our products also feature a safer bottling and packaging practices, ensuring reliability and safety. In addition, Sarmsamerica is reputed for fast shipping and excellent customer service, making it a reliable option amidst the many sites offering Testolone and related substances on the internet.

It’s crucial to purchase from websites that prioritize quality-control procedures over quick profits. This ensures that customers receive dependable products that meet the advertised standards.

When you buy SARMs from Sarmsamerica, you are opting for the highest quality ingredients available. Their products boast a minimum purity of 98%, verified through testing and certification by accredited American third-party laboratories. These compounds are suspended in USP grade (the highest grade) PEG400 and bottled in America, ensuring reliability and adherence to stringent quality standards.

We operate a transparent business, eliminating the need for discreet payment methods and ensuring no misrepresentation of our products. We offer only the highest quality research chemicals available online. Orders totaling $160 or more qualify for free shipping, and we also offer express shipping options for customers who need their products expedited.

In addition, customers who join our email list enjoy a 10% discount on their purchases. At Sarmsamerica, we offer RAD140 in pure powder form, ensuring flexibility and purity in your research needs. Choose Sarmsamerica for the best place to buy RAD140, backed by our commitment to quality and customer satisfaction. Our Rad-140 is also available in SARMs stack with 20% off.

We are dedicated to providing top-tier customer service. Please feel free to contact us with any questions or concerns you may have regarding our RAD140 for sale. Your satisfaction and peace of mind are our priorities.

Abuse Warning

RAD 140 is an investigational compound that has not yet received FDA approval and is not classified as a dietary supplement. At Sarmsamerica, we specialize in chemical sourcing and quality control. We want to emphasize that we are chemical suppliers, not medical doctors, and our products are intended solely for research purposes. Sarmsamerica does not promote or endorse the use of SARMs products by consumers.

SARMs should only be used under the supervision and guidance of a medical doctor or authorized research authority. At Sarmsamerica, we strongly discourage the use of SARMs for performance enhancement in sports and bodybuilding. It’s important to rely on evidence-based research and expert advice rather than anecdotal information or peer consensus when making decisions about human health.

Scientific References:

1. Miller, C. P., Shomali, M., Lyttle, C. R., O’Dea, L. S., Herendeen, H., Gallacher, K., Paquin, D., Compton, D. R., Sahoo, B., Kerrigan, S. A., Burge, M. S., Nickels, M., Green, J. L., Katzenellenbogen, J. A., Tchesnokov, A., & Hattersley, G. (2010). Design, Synthesis, and Preclinical Characterization of the Selective AR Modulator (SARM) RAD140. ACS medicinal chemistry letters, 2(2), 124–129.
2. Jayaraman, A., Christensen, A., Moser, V. A., Vest, R. S., Miller, C. P., Hattersley, G., & Pike, C. J. (2014). Selective AR modulator RAD140 is neuroprotective in cultured neurons and kinate-lesioned male rats. Endocrinology, 155(4), 1398–1406.
3. D. K. Hamson, S. R. Wainwright, J. R. Taylor, B. A. Jones, N. V. Watson, L. A. M. Galea, Androgens Increase Survival of Adult-Born Neurons in the Dentate Gyrus by an Androgen Receptor-Dependent Mechanism in Male Rats, Endocrinology, Volume 154, Issue 9, 1 September 2013, Pages 3294–3304
4. Yu, Ziyang et al. “Selective Androgen Receptor Modulator RAD140 Inhibits the Growth of Androgen/Estrogen Receptor–Positive BC Models with a Distinct Mechanism of Action.” MK 677 Clinical Cancer Research23 (2017): 7608 – 7620.
5. LoRusso P, Hamilton E, Ma C, Vidula N, Bagley RG, Troy S, Annett M, Yu Z, Conlan MG, Weise A. A First-in-Human Phase 1 Study of a Novel Selective AR Modulator (SARM), RAD140, in ER+/HER2- Metastatic BC. Clin Br Cancer. 2022Jan;22(1):67-77. doi: 10.1016/j.clbc.2021.08.003. Epub 2021 Aug 20. PMID: 34565686.
6. Puskas, J. (2022). Pre-clinical assessment of the selective androgen receptor modulator RAD140 to increase muscle mass and bone mineral density (Doctoral dissertation).
7. Flores JE, Chitturi S, Walker S. Drug-Induced Liver Injury by Selective Androgenic Receptor Modulators. Hepatol Commun. 2020Jan 3;4(3):450-452. doi: 10.1002/hep4.1456. PMID: 32140660; PMCID: PMC7049679.
8. Bing L, Wu J, Zhang J, Chen Y, Hong Z, Zu H. DHT inhibits the Aβ25-35-induced apoptosis by regulation of seladin-1, survivin, XIAP, bax, and bcl-xl expression through a rapid PI3-K/Akt signaling in C6 glial cell lines. Neurochem Res. 2014;40(1):41–48.
9. Huo DS, Sun JF, Zhang B, Yan XS, Wang H, Jia JX, Yang ZJ. Protective effects of testosterone on cognitive dysfunction in Alzheimer’s disease model rats induced by oligomeric beta amyloid peptide 1–42. J Toxicol Environ Health A. 2016;79(19):856–863.
10. Van Wagoner RM, Eichner A, Bhasin S, Deuster PA, Eichner D. Chemical Composition and Labeling of Substances Marketed as Selective Androgen Receptor Modulators and Sold via the Internet. JAMA. 2017 Nov 28;318(20):2004-2010. doi: 10.1001/jama.2017.17069. Erratum in: JAMA. 2018Feb 20;319(7):724. PMID: 29183075; PMCID: PMC5820696.
11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959610/
12. https://clincancerres.aacrjournals.org/content/23/24/7608
13. https://cancerres.aacrjournals.org/content/80/4_Supplement/P5-11-01